Across TCGA pan-cancer cohorts, MVB12B mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated MVB12B data layer compared with 24 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher MVB12B mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated MVB12B expression acts as an unfavorable survival marker, although some lineages such as CCRCC and UCEC show a favorable association.

CCRCC, GBM, and UCEC are the cancer types where MVB12B mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	OS	Median	All	1.000	0.698	.009	17	view →
GBM	OS	Median	All	0.356	0.654	.006	9	view →
UCEC	DFS	Tertile	All	1.000	0.844	.011	8	view →
LSCC	OS	Median	All	0.881	0.743	.024	2	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

Exploration

Same gene, other analysis: MVB12B tumor-vs-normal RNA expression · all MVB12B data types