Across TCGA patient cohorts, MVB12B protein abundance is significantly associated with the RNA expression of many other genes, with 8,559 significant associations in total. GBM shows the largest number of these associations.

The most reproducible MVB12B-associated genes across cancer lineages are SHE, PTPRN2, and C14orf132. Each is linked with MVB12B in more than 4 cancer types. Because this analysis shows association rather than direction, both MVB12B-to-partner and partner-to-MVB12B results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MVB12B→partner) and Y-score (partner→MVB12B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SHE →	+0.688	+0.335	<.001	<.001	3	5
BRCA	PTPRN2 →	+1.561	+0.292	<.001	.001	3	4
UCEC	C14orf132 →	+0.996	+0.267	.004	.002	3	4
UCEC	CHRDL1 →	+1.585	+0.312	<.001	.005	3	3
BRCA	FHL5 →	+0.823	+0.332	<.001	<.001	3	3
GBM	PDE1A →	+1.136	+0.331	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 8,559 associations by consensus.

Exploration

MVB12B survival (RNA) · tumor vs normal (RNA) · all MVB12B data types