Across TCGA patient cohorts, MVB12B mutation is significantly associated with the total protein of many other genes, with 8 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MVB12B-associated genes across cancer lineages are ATM, GATA6, and Ku80. Each is linked with MVB12B in more than 1 cancer types. Because this analysis shows association rather than direction, both MVB12B-to-partner and partner-to-MVB12B results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MVB12B→partner) and Y-score (partner→MVB12B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.544	-2.986	.010	.035	3	2
UCEC	GATA6 →	-0.167	-3.169	.025	.019	3	1
UCEC	Ku80 →	+0.317	+1.887	.004	.031	3	1
UCEC	MEK1 →	+0.343	+2.321	.044	.034	3	1
UCEC	Notch1 →	+0.171	+2.179	.009	.034	3	1
UCEC	p62 Lck ligand →	+0.370	+2.179	.014	.034	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

Exploration

MVB12B survival (RNA) · tumor vs normal (RNA) · all MVB12B data types