MVB12A

Across TCGA pan-cancer cohorts, MVB12A mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated MVB12A data layer compared with 21 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher MVB12A mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated MVB12A expression acts as an unfavorable survival marker.

LSCC, GBM, and PDAC are the cancer types where MVB12A mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	DFS	Tertile	All	0.437	1.000	.006	6	view →
GBM	DFS	Quartile	All	0.261	0.478	.016	3	view →
PDAC	DFS	Median	III,IV	0.477	0.796	.044	1	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

MVB12A–LSCC (DFS)

Open the LSCC breakdown →