MVB12A

Across TCGA patient cohorts, MVB12A mutation is significantly associated with the RNA expression of many other genes, with 151 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MVB12A-associated genes across cancer lineages are RNU6-236P, MIR6839, and RNA5SP358. Each is linked with MVB12A in more than 2 cancer types. Because this analysis shows association rather than direction, both MVB12A-to-partner and partner-to-MVB12A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-236P grouped by MVB12A-low versus MVB12A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MVB12A→partner) and Y-score (partner→MVB12A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNU6-236P →	+0.554	+3.193	<.001	.001	3	3
UCEC	MIR6839 →	+0.471	+3.714	<.001	<.001	3	2
LUAD	RNA5SP358 →	+0.628	+6.569	<.001	<.001	3	2
LUAD	RN7SL380P →	+0.132	+4.888	<.001	.005	3	2
LUAD	SUGT1P4 →	+0.233	+5.087	<.001	.004	3	2
SKCM	DEFB136 →	+0.489	+4.313	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 151 associations by consensus.

RNU6-236P by MVB12A expression — UCEC

Explore this box plot interactively →