MVB12A

Across TCGA patient cohorts, MVB12A mutation is significantly associated with the total protein of many other genes, with 4 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible MVB12A-associated genes across cancer lineages are GSK-3a-b_pS21_S9, p62 Lck ligand, and AR. Each is linked with MVB12A in more than 1 cancer types. Because this analysis shows association rather than direction, both MVB12A-to-partner and partner-to-MVB12A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GSK-3a-b_pS21_S9 grouped by MVB12A-low versus MVB12A-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MVB12A→partner) and Y-score (partner→MVB12A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	GSK-3a-b_pS21_S9 →	-0.529	-3.000	.027	.036	3	1
SKCM	p62 Lck ligand →	+0.760	+3.000	<.001	.036	3	1
SKCM	AR →	+0.228	+3.000	.009	.036	3	1
SKCM	PKC-a →	+0.534	+3.000	.021	.036	1	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

GSK-3a-b_pS21_S9 by MVB12A expression — SKCM

Explore this box plot interactively →