MUTYH

Across TCGA patient cohorts, MUTYH RNA expression is significantly associated with the protein abundance of many other proteins, with 12,806 significant associations in total. GBM shows the largest number of these associations.

The most reproducible MUTYH-associated proteins across cancer lineages are NASP, SMC1A, and TOE1. Each is linked with MUTYH in more than 4 cancer types. Because this analysis shows association rather than direction, both MUTYH-to-partner and partner-to-MUTYH results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, MUTYH versus NASP in GBM, with a Pearson correlation of 0.55.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (MUTYH→partner) and Y-score (partner→MUTYH) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	NASP →	+0.510	+0.236	<.001	<.001	3	5
GBM	SMC1A →	+0.340	+0.255	<.001	<.001	3	5
OV	TOE1 →	+0.390	+0.217	<.001	.007	3	5
GBM	PPP1R8 →	+0.198	+0.234	<.001	<.001	3	5
GBM	RAD21 →	+0.323	+0.238	<.001	<.001	3	5
GBM	RSF1 →	+0.335	+0.252	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 12,806 associations by consensus.

MUTYH vs NASP — GBM

Explore this scatter interactively →