MUTYH

Across TCGA patient cohorts, MUTYH mutation is significantly associated with the RNA expression of many other genes, with 2,283 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MUTYH-associated genes across cancer lineages are ANP32BP2, MIR4487, and POLR2C. Each is linked with MUTYH in more than 2 cancer types. Because this analysis shows association rather than direction, both MUTYH-to-partner and partner-to-MUTYH results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ANP32BP2 grouped by MUTYH-low versus MUTYH-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MUTYH→partner) and Y-score (partner→MUTYH) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ANP32BP2 →	+0.102	+1.776	.008	.004	3	3
KIRP	MIR4487 →	+0.734	+5.264	<.001	.006	3	2
UCEC	POLR2C →	+0.374	+1.858	.006	.005	3	2
UCEC	BMF →	-0.786	-2.237	<.001	.002	3	2
UCEC	KCTD9 →	+0.661	+1.858	<.001	.005	3	2
UCEC	TMEM33 →	+0.469	+3.343	.005	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,283 associations by consensus.

ANP32BP2 by MUTYH expression — UCEC

Explore this box plot interactively →