MUTYH

Across TCGA patient cohorts, MUTYH mutation is significantly associated with the total protein of many other genes, with 20 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MUTYH-associated genes across cancer lineages are ATM, Caspase-7-cleavedD198, and EGFR_pY1068. Each is linked with MUTYH in more than 1 cancer types. Because this analysis shows association rather than direction, both MUTYH-to-partner and partner-to-MUTYH results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by MUTYH-low versus MUTYH-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MUTYH→partner) and Y-score (partner→MUTYH) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.469	-2.459	.012	.019	3	2
UCEC	Caspase-7-cleavedD198 →	+0.718	+2.321	.003	.006	3	2
UCEC	EGFR_pY1068 →	-0.230	-2.459	.026	.019	3	1
UCEC	EGFR →	-0.192	-1.807	.003	.027	3	1
UCEC	ERK2 →	+0.197	+3.169	.013	.018	3	1
UCEC	MEK1 →	+0.403	+1.807	.007	.027	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 20 associations by consensus.

ATM by MUTYH expression — UCEC

Explore this box plot interactively →