MUTYH

Across TCGA cell cohorts, MUTYH RNA expression is significantly associated with the go_rna of many other GO terms, with 4,220 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible MUTYH-associated GO terms across cancer lineages are Telomere organization, Telomere maintenance, and Mismatch repair. Each is linked with MUTYH in more than 15 cancer types. Because this analysis shows association rather than direction, both MUTYH-to-partner and partner-to-MUTYH results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Telomere organization grouped by MUTYH-low versus MUTYH-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (MUTYH→partner) and Y-score (partner→MUTYH) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Telomere organization →	+0.090	+1.093	<.001	<.001	3	16
UPPER_AERODIGESTIVE_TRACT	Telomere maintenance →	+0.091	+1.177	<.001	<.001	3	15
SOFT_TISSUE	Mismatch repair →	+0.113	+0.937	<.001	<.001	3	14
BONE	Co-transcriptional RNA 3'-end processing, cleavage and polyadenylation pathway →	+0.141	+0.722	.002	.006	3	13
LARGE_INTESTINE	Positive regulation of DNA metabolic process →	+0.061	+0.785	<.001	<.001	3	13
LARGE_INTESTINE	Double-strand break repair →	+0.061	+0.857	<.001	<.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,220 associations by consensus.

Telomere organization by MUTYH expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →