MUTYH

Across TCGA cell cohorts, MUTYH mutation is significantly associated with the RNA expression of many other genes, with 33 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible MUTYH-associated genes across cancer lineages are GYPB, LIPK, and OR4D5. Each is linked with MUTYH in more than 1 cancer types. Because this analysis shows association rather than direction, both MUTYH-to-partner and partner-to-MUTYH results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GYPB grouped by MUTYH-low versus MUTYH-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MUTYH→partner) and Y-score (partner→MUTYH) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	GYPB →	+0.076	+3.544	.002	.009	3	2
SOFT_TISSUE	LIPK →	+0.032	+4.930	<.001	.008	3	1
BONE	OR4D5 →	+0.030	+5.169	<.001	.004	3	1
LARGE_INTESTINE	PRSS54 →	+0.038	+3.345	<.001	.007	3	1
LARGE_INTESTINE	REG1B →	+2.080	+4.518	.001	<.001	3	1
LARGE_INTESTINE	OR10W1 →	+0.016	+3.977	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 33 associations by consensus.

GYPB by MUTYH expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →