MUSK

Across TCGA pan-cancer cohorts, MUSK mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated MUSK data layer compared with 19 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher MUSK mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated MUSK expression acts as an unfavorable survival marker, although some lineages such as LUAD and PDAC show a favorable association.

LUAD, PDAC, and GBM are the cancer types where MUSK mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Median	III,IV	1.000	0.268	.013	15	view →
PDAC	OS	Tertile	All	0.697	0.262	.004	9	view →
GBM	DFS	Quartile	All	0.971	0.601	.041	1	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

MUSK–LUAD (OS)

Open the LUAD breakdown →