MUS81

Across TCGA pan-cancer cohorts, MUS81 Mutation is linked to patient survival in 6 of 34 cancer types, making it a survival-associated MUS81 data layer compared with 29 for mass-spec protein and 2 for mass-spec protein.

The strongest signal is observed in thymoma (THYM), where higher MUS81 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated MUS81 expression acts as an unfavorable survival marker, although some lineages such as SKCM show a favorable association.

THYM, ACC, and COAD are the cancer types where MUS81 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
THYM	OS	Median	III,IV	0.103	0.944	<.001	42	view →
ACC	OS	Median	All	0.118	0.624	.038	6	view →
COAD	DFS	Median	All	0.105	0.559	.006	6	view →
PRAD	DFS	Median	All	0.085	0.774	<.001	6	view →
UCEC	OS	Median	IV	0.231	0.592	.036	6	view →
SKCM	OS	Median	II,III,IV	1.000	0.306	.037	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

MUS81–THYM (OS)

Open the THYM breakdown →