MUS81

Across TCGA pan-cancer cohorts, MUS81 mass-spec protein is linked to patient survival in 2 of 34 cancer types, making it a survival-associated MUS81 data layer compared with 29 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher MUS81 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated MUS81 expression acts as an unfavorable survival marker, although some lineages such as HNSC show a favorable association.

HNSC and GBM are the cancer types where MUS81 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	All	0.856	0.509	.043	10	view →
GBM	DFS	Quartile	All	0.260	0.974	.038	8	view →

Pink = unfavorable, green = favorable. Showing the 2 strongest of 2 lineages.

MUS81–HNSC (OS)

Open the HNSC breakdown →