MUS81

Across TCGA cell cohorts, MUS81 mutation is significantly associated with the RNA expression of many other genes, with 13 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MUS81-associated genes across cancer lineages are IL3, KRTAP19-4, and OR2C3. Each is linked with MUS81 in more than 1 cancer types. Because this analysis shows association rather than direction, both MUS81-to-partner and partner-to-MUS81 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IL3 grouped by MUS81-low versus MUS81-high in URINARY_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MUS81→partner) and Y-score (partner→MUS81) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	IL3 →	+0.026	+5.087	<.001	.004	3	1
URINARY_TRACT	KRTAP19-4 →	+0.193	+5.087	<.001	.004	3	1
URINARY_TRACT	OR2C3 →	+0.030	+5.087	<.001	.004	3	1
URINARY_TRACT	KRTAP6-3 →	+0.126	+5.087	<.001	.004	3	1
OVARY	ENPP7 →	+0.021	+4.029	.005	.009	3	1
LARGE_INTESTINE	NPFF →	+0.121	+3.541	.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

IL3 by MUS81 expression — URINARY_TRACT

Explore this box plot interactively →