MUCL3

Across TCGA pan-cancer cohorts, MUCL3 Mutation is linked to patient survival in 10 of 34 cancer types, making it a survival-associated MUCL3 data layer compared with 21 for mass-spec protein and 1 for mass-spec protein.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher MUCL3 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated MUCL3 expression acts as an unfavorable survival marker.

KIRC, READ, and BLCA are the cancer types where MUCL3 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	OS	Median	All	0.054	0.881	<.001	48	view →
READ	OS	Median	All	0.198	0.829	.001	20	view →
BLCA	OS	Median	All	0.197	0.720	.004	18	view →
COAD	OS	Median	III,IV	0.159	0.692	.021	16	view →
SKCM	OS	Median	All	0.222	0.788	<.001	15	view →
LIHC	DFS	Median	All	0.077	0.527	.002	9	view →
SARC	DFS	Median	All	0.173	0.612	.020	6	view →
BRCA	DFS	Median	All	0.206	0.529	.017	6	view →
UCEC	OS	Median	IV	0.231	0.592	.036	6	view →
SCLC	OS	Median	II,III,IV	0.152	0.777	.038	3	view →

Pink = unfavorable, green = favorable. Showing the 10 strongest of 10 lineages.

MUCL3–KIRC (OS)

Open the KIRC breakdown →