MUCL3

Across TCGA cell cohorts, MUCL3 mutation is significantly associated with the RNA expression of many other genes, with 349 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MUCL3-associated genes across cancer lineages are ZAN, KCNK18, and MMD2. Each is linked with MUCL3 in more than 1 cancer types. Because this analysis shows association rather than direction, both MUCL3-to-partner and partner-to-MUCL3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ZAN grouped by MUCL3-low versus MUCL3-high in URINARY_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MUCL3→partner) and Y-score (partner→MUCL3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	ZAN →	+0.006	+5.087	<.001	.004	3	2
OESOPHAGUS	KCNK18 →	+0.020	+4.906	<.001	.006	3	2
URINARY_TRACT	MMD2 →	+0.063	+5.087	<.001	.004	3	1
SOFT_TISSUE	LALBA →	+1.528	+4.882	<.001	.001	3	1
SOFT_TISSUE	CCR8 →	+0.016	+4.369	<.001	.008	3	1
SOFT_TISSUE	TEX49 →	+0.641	+4.882	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 349 associations by consensus.

ZAN by MUCL3 expression — URINARY_TRACT

Explore this box plot interactively →