MUCL1

Across TCGA patient cohorts, MUCL1 mutation is significantly associated with the RNA expression of many other genes, with 416 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible MUCL1-associated genes across cancer lineages are RPL26P29, MTCO1P27, and RNA5SP419. Each is linked with MUCL1 in more than 1 cancer types. Because this analysis shows association rather than direction, both MUCL1-to-partner and partner-to-MUCL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RPL26P29 grouped by MUCL1-low versus MUCL1-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MUCL1→partner) and Y-score (partner→MUCL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	RPL26P29 →	+0.192	+3.847	.001	<.001	3	2
UCEC	MTCO1P27 →	+0.426	+3.062	.007	.005	3	2
UCEC	RNA5SP419 →	+0.958	+3.077	<.001	.005	3	2
SKCM	ANKMY2 →	+0.597	+2.591	.008	.006	3	2
SKCM	CDK2AP1 →	+0.633	+2.604	.003	.006	3	2
SKCM	BRD8 →	+0.628	+3.706	.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 416 associations by consensus.

RPL26P29 by MUCL1 expression — SKCM

Explore this box plot interactively →