Across TCGA patient cohorts, MUC6 mutation is significantly associated with the RNA expression of many other genes, with 4,325 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MUC6-associated genes across cancer lineages are HMG20B, RASSF1, and LACTB. Each is linked with MUC6 in more than 3 cancer types. Because this analysis shows association rather than direction, both MUC6-to-partner and partner-to-MUC6 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MUC6→partner) and Y-score (partner→MUC6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	HMG20B →	+0.484	+2.828	<.001	<.001	3	4
STAD	RASSF1 →	+0.385	+2.165	.007	.009	3	4
UCEC	LACTB →	+0.396	+3.424	<.001	<.001	3	4
STAD	TXNL4A →	+0.438	+3.906	.001	<.001	3	4
STAD	LYG1 →	+0.568	+3.359	.001	.004	3	4
UCEC	CORT →	+0.412	+1.981	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,325 associations by consensus.

Exploration

MUC6 survival (RNA) · tumor vs normal (RNA) · all MUC6 data types