Across TCGA patient cohorts, MUC6 mutation is significantly associated with the total protein of many other genes, with 53 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MUC6-associated genes across cancer lineages are eEF2, N-Ras, and TIGAR. Each is linked with MUC6 in more than 2 cancer types. Because this analysis shows association rather than direction, both MUC6-to-partner and partner-to-MUC6 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MUC6→partner) and Y-score (partner→MUC6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	eEF2 →	+0.319	+2.584	.011	.010	3	3
UCEC	N-Ras →	-0.070	-1.780	.043	.024	3	3
STAD	TIGAR →	+0.358	+2.584	.037	.010	3	2
UCEC	Cyclin-B1 →	+0.476	+1.925	.003	.004	3	2
UCEC	PCNA →	+0.181	+1.295	.003	.010	3	2
UCEC	ATM →	-0.589	-1.906	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 53 associations by consensus.

Exploration

MUC6 survival (RNA) · tumor vs normal (RNA) · all MUC6 data types