Across TCGA cell cohorts, MUC6 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,402 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible MUC6-associated GO terms across cancer lineages are U2-type prespliceosome assembly, Protein linear polyubiquitination, and Cytoplasm protein quality control by the ubiquitin-proteasome system. Each is linked with MUC6 in more than 7 cancer types. Because this analysis shows association rather than direction, both MUC6-to-partner and partner-to-MUC6 results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (MUC6→partner) and Y-score (partner→MUC6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	U2-type prespliceosome assembly →	+0.108	+0.231	<.001	.002	3	8
BLOOD_Leukemia	Protein linear polyubiquitination →	+0.074	+0.103	<.001	.001	3	8
BONE	Cytoplasm protein quality control by the ubiquitin-proteasome system →	+0.189	+0.358	<.001	.003	3	8
BONE	Negative regulation of DNA-templated transcription, elongation →	+0.114	+0.174	.001	.001	3	7
BONE	Positive regulation of intracellular estrogen receptor signaling pathway →	+0.216	+0.290	<.001	<.001	2	8
UPPER_AERODIGESTIVE_TRACT	Negative regulation of transcription elongation by RNA polymerase II →	+0.127	+0.170	<.001	.006	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,402 associations by consensus.

Exploration

MUC6 survival (RNA) · tumor vs normal (RNA) · all MUC6 data types