MUC4

Across TCGA pan-cancer cohorts, MUC4 Mutation is linked to patient survival in 9 of 34 cancer types, making it a survival-associated MUC4 data layer compared with 23 for mass-spec protein and 4 for mass-spec protein.

The strongest signal is observed in liver hepatocellular carcinoma (LIHC), where higher MUC4 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated MUC4 expression acts as an unfavorable survival marker, although some lineages such as UCEC and READ show a favorable association.

LIHC, ACC, and COAD are the cancer types where MUC4 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LIHC	OS	Median	All	0.366	0.691	.001	20	view →
ACC	OS	Median	All	0.309	0.657	.001	15	view →
COAD	DFS	Median	All	0.338	0.538	.018	9	view →
UCEC	OS	Median	All	0.786	0.645	.012	8	view →
KICH	OS	Median	III,IV	0.178	0.847	<.001	6	view →
LUAD	OS	Median	All	0.568	0.815	.007	6	view →
SKCM	OS	Median	IV	0.133	0.621	.019	6	view →
READ	DFS	Median	All	1.000	0.507	.048	2	view →
LUSC	DFS	Median	III,IV	1.000	0.345	.042	1	view →

Pink = unfavorable, green = favorable. Showing the 9 strongest of 9 lineages.

MUC4–LIHC (OS)

Open the LIHC breakdown →