MUC4

Across TCGA pan-cancer cohorts, MUC4 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated MUC4 data layer compared with 23 for mass-spec protein and 9 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher MUC4 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated MUC4 expression acts as an unfavorable survival marker, although some lineages such as LSCC show a favorable association.

PDAC, LUAD, and HNSC are the cancer types where MUC4 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	OS	Tertile	IV	0.231	0.916	.024	11	view →
LUAD	OS	Median	II,III,IV	0.391	0.782	.013	7	view →
HNSC	OS	Tertile	II,III,IV	0.943	1.000	.035	2	view →
LSCC	DFS	Median	III,IV	1.000	0.867	.045	1	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

MUC4–PDAC (OS)

Open the PDAC breakdown →