MUC4

Across TCGA patient cohorts, MUC4 mutation is significantly associated with the total protein of many other genes, with 89 significant associations in total. COAD shows the largest number of these associations.

The most reproducible MUC4-associated genes across cancer lineages are FASN, Caspase-7-cleavedD198, and c-Kit. Each is linked with MUC4 in more than 3 cancer types. Because this analysis shows association rather than direction, both MUC4-to-partner and partner-to-MUC4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FASN grouped by MUC4-low versus MUC4-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MUC4→partner) and Y-score (partner→MUC4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	FASN →	+0.400	+2.185	.017	.032	3	4
COAD	Caspase-7-cleavedD198 →	+0.699	+1.431	.001	.023	3	4
STAD	c-Kit →	-0.364	-2.700	.004	.005	3	4
STAD	Cyclin-B1 →	+0.407	+2.000	.030	.030	3	4
COAD	S6_pS240_S244 →	+0.309	+1.807	.004	.022	3	4
STAD	eIF4E →	+0.229	+2.000	.001	.030	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 89 associations by consensus.

FASN by MUC4 expression — STAD

Explore this box plot interactively →