MUC3A

Across TCGA pan-cancer cohorts, MUC3A Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated MUC3A data layer compared with 25 for mass-spec protein and 1 for mass-spec protein.

The strongest signal is observed in brain lower grade glioma (LGG), where higher MUC3A Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated MUC3A expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

LGG, BRCA, and LUAD are the cancer types where MUC3A Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LGG	OS	Median	All	0.088	0.909	<.001	12	view →
BRCA	OS	Median	All	0.131	0.578	.011	12	view →
LUAD	OS	Median	III,IV	0.004	0.665	<.001	12	view →
UCEC	DFS	Median	II,III,IV	0.915	0.438	.033	8	view →
LUSC	OS	Median	II,III,IV	0.191	0.424	.047	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

MUC3A–LGG (OS)

Open the LGG breakdown →