MUC22

Across TCGA cell cohorts, MUC22 mutation is significantly associated with the RNA expression of many other genes, with 77 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MUC22-associated genes across cancer lineages are ANKRD30BL, PABPC1L2A, and OPRPN. Each is linked with MUC22 in more than 1 cancer types. Because this analysis shows association rather than direction, both MUC22-to-partner and partner-to-MUC22 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ANKRD30BL grouped by MUC22-low versus MUC22-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MUC22→partner) and Y-score (partner→MUC22) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	ANKRD30BL →	+0.130	+3.832	.006	.001	3	2
SOFT_TISSUE	PABPC1L2A →	+0.109	+3.459	<.001	.003	3	2
BREAST	OPRPN →	+0.496	+3.781	.002	.009	3	2
BLOOD_Leukemia	BPIFB6 →	+0.047	+4.969	<.001	.003	3	2
SOFT_TISSUE	KHDRBS2 →	+0.822	+3.819	<.001	.003	3	1
LUNG_NSCLC_LUSC	TMIGD3 →	+0.049	+3.000	.002	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 77 associations by consensus.

ANKRD30BL by MUC22 expression — SOFT_TISSUE

Explore this box plot interactively →