Across TCGA patient cohorts, MUC21 mutation is significantly associated with the total protein of many other genes, with 28 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MUC21-associated genes across cancer lineages are EGFR_pY1068, MSH2, and Caspase-7-cleavedD198. Each is linked with MUC21 in more than 1 cancer types. Because this analysis shows association rather than direction, both MUC21-to-partner and partner-to-MUC21 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MUC21→partner) and Y-score (partner→MUC21) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.222	-1.906	.027	.016	3	2
UCEC	MSH2 →	-0.214	-2.973	.021	.035	3	2
UCEC	Caspase-7-cleavedD198 →	+0.511	+2.341	.032	.019	3	2
UCEC	ERK2 →	+0.199	+2.321	.010	.034	3	1
UCEC	FoxM1 →	+0.205	+2.415	.049	.003	3	1
UCEC	Gab2 →	+0.449	+2.459	.001	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 28 associations by consensus.

Exploration

MUC21 survival (RNA) · tumor vs normal (RNA) · all MUC21 data types