Across TCGA cell cohorts, MUC21 RNA expression is significantly associated with the go_rna of many other GO terms, with 1,229 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible MUC21-associated GO terms across cancer lineages are Negative regulation of macroautophagy, T cell mediated cytotoxicity, and Autophagosome organization. Each is linked with MUC21 in more than 4 cancer types. Because this analysis shows association rather than direction, both MUC21-to-partner and partner-to-MUC21 results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (MUC21→partner) and Y-score (partner→MUC21) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Negative regulation of macroautophagy →	+0.059	+0.116	.008	.009	3	5
LUNG_NSCLC_LUAD	T cell mediated cytotoxicity →	+0.222	+1.754	<.001	.001	3	5
BLOOD_Leukemia	Autophagosome organization →	+0.025	+0.013	.002	.002	3	5
BLOOD_Leukemia	Signal transduction in response to DNA damage →	+0.032	+0.019	.001	.006	3	5
LIVER	Positive regulation of iron ion transport →	+1.753	+0.050	<.001	.005	3	5
LIVER	Positive regulation of iron ion transmembrane transport →	+1.753	+0.050	<.001	.005	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,229 associations by consensus.

Exploration

MUC21 survival (RNA) · tumor vs normal (RNA) · all MUC21 data types