MUC20-OT1

Across TCGA pan-cancer cohorts, MUC20-OT1 Mutation is linked to patient survival in 6 of 34 cancer types, making it a survival-associated MUC20-OT1 data layer compared with 22 for mass-spec protein.

The strongest signal is observed in esophageal carcinoma (ESCA), where higher MUC20-OT1 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated MUC20-OT1 expression acts as an unfavorable survival marker.

ESCA, OV, and UCEC are the cancer types where MUC20-OT1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ESCA	OS	Median	II,III,IV	0.108	0.703	<.001	36	view →
OV	DFS	Median	II,III,IV	0.193	0.541	.013	18	view →
UCEC	OS	Median	IV	0.066	0.755	<.001	12	view →
BLCA	OS	Median	All	0.212	0.720	.007	12	view →
BRCA	OS	Median	All	0.151	0.579	.009	8	view →
SKCM	OS	Median	III,IV	0.233	0.705	.034	3	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

MUC20-OT1–ESCA (OS)

Open the ESCA breakdown →