Across TCGA patient cohorts, MUC19 mutation is significantly associated with the RNA expression of many other genes, with 5,444 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MUC19-associated genes across cancer lineages are PYROXD1, POC1B, and AAGAB. Each is linked with MUC19 in more than 2 cancer types. Because this analysis shows association rather than direction, both MUC19-to-partner and partner-to-MUC19 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MUC19→partner) and Y-score (partner→MUC19) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	PYROXD1 →	+0.874	+3.209	<.001	.009	3	3
UCEC	POC1B →	+0.601	+2.523	<.001	<.001	3	3
UCEC	AAGAB →	+0.637	+3.412	<.001	<.001	3	3
UCEC	FOXN1 →	-0.361	-2.382	.007	.003	3	3
UCEC	NR2C1 →	+0.423	+2.673	<.001	<.001	3	3
UCEC	ZNF714 →	+0.500	+1.958	.002	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,444 associations by consensus.

Exploration

MUC19 survival (RNA) · tumor vs normal (RNA) · all MUC19 data types