Across TCGA patient cohorts, MUC19 mutation is significantly associated with the total protein of many other genes, with 46 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MUC19-associated genes across cancer lineages are Bax, eEF2, and EGFR_pY1068. Each is linked with MUC19 in more than 2 cancer types. Because this analysis shows association rather than direction, both MUC19-to-partner and partner-to-MUC19 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MUC19→partner) and Y-score (partner→MUC19) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Bax →	+0.190	+1.817	.022	.015	3	3
UCEC	eEF2 →	+0.349	+2.459	.004	.018	3	2
UCEC	EGFR_pY1068 →	-0.354	-2.938	<.001	<.001	3	2
UCEC	ERK2 →	+0.172	+1.440	.009	.024	3	2
UCEC	GATA6 →	-0.161	-2.307	.005	.033	3	2
UCEC	INPP4B →	-0.265	-2.584	.018	.010	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 46 associations by consensus.

Exploration

MUC19 survival (RNA) · tumor vs normal (RNA) · all MUC19 data types