MUC17

Across TCGA patient cohorts, MUC17 mutation is significantly associated with the RNA expression of many other genes, with 13,305 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MUC17-associated genes across cancer lineages are SPC24, MTHFD2, and ARHGAP11A. Each is linked with MUC17 in more than 8 cancer types. Because this analysis shows association rather than direction, both MUC17-to-partner and partner-to-MUC17 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SPC24 grouped by MUC17-low versus MUC17-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MUC17→partner) and Y-score (partner→MUC17) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	SPC24 →	+0.588	+1.731	<.001	<.001	3	9
COAD	MTHFD2 →	+0.553	+1.834	<.001	<.001	3	8
STAD	ARHGAP11A →	+0.695	+2.840	<.001	.001	3	8
LUAD	CDC45 →	+0.867	+1.308	<.001	<.001	3	8
UCEC	OIP5 →	+0.792	+1.978	<.001	<.001	3	8
LUAD	CENPA →	+0.807	+1.518	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 13,305 associations by consensus.

SPC24 by MUC17 expression — LUAD

Explore this box plot interactively →