MUC17

Across TCGA patient cohorts, MUC17 mutation is significantly associated with the total protein of many other genes, with 123 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MUC17-associated genes across cancer lineages are TFRC, ASNS, and GAPDH. Each is linked with MUC17 in more than 6 cancer types. Because this analysis shows association rather than direction, both MUC17-to-partner and partner-to-MUC17 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TFRC grouped by MUC17-low versus MUC17-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MUC17→partner) and Y-score (partner→MUC17) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TFRC →	+0.459	+2.201	<.001	<.001	3	7
COAD	ASNS →	+0.396	+1.256	.001	.028	3	7
COAD	GAPDH →	+0.562	+2.807	<.001	.002	3	7
COAD	PCNA →	+0.254	+1.815	<.001	.002	3	6
LUAD	Cyclin-E1 →	+0.197	+1.137	.001	.030	3	5
LUAD	Fibronectin →	+0.335	+1.765	.007	.010	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 123 associations by consensus.

TFRC by MUC17 expression — UCEC

Explore this box plot interactively →