MUC17

Across TCGA cell cohorts, MUC17 mutation is significantly associated with the RNA expression of many other genes, with 1,951 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MUC17-associated genes across cancer lineages are ADAM22, CYB5D1, and HMG20B. Each is linked with MUC17 in more than 3 cancer types. Because this analysis shows association rather than direction, both MUC17-to-partner and partner-to-MUC17 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ADAM22 grouped by MUC17-low versus MUC17-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MUC17→partner) and Y-score (partner→MUC17) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ADAM22 →	+0.772	+2.807	<.001	<.001	3	4
LARGE_INTESTINE	CYB5D1 →	+0.950	+2.286	<.001	<.001	3	4
LARGE_INTESTINE	HMG20B →	+0.606	+2.700	.002	.001	3	4
STOMACH	MROH9 →	+0.023	+2.847	<.001	.003	3	3
OESOPHAGUS	SAPCD2 →	+0.927	+3.321	.003	.002	3	3
BLOOD_Myeloma	SPEM1 →	+0.020	+3.169	<.001	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,951 associations by consensus.

ADAM22 by MUC17 expression — LARGE_INTESTINE

Explore this box plot interactively →