MUC15

Across TCGA pan-cancer cohorts, MUC15 Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated MUC15 data layer compared with 25 for mass-spec protein and 4 for mass-spec protein.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher MUC15 Mutation is associated with better disease-free survival. In most high-consensus cancer types, elevated MUC15 expression acts as an unfavorable survival marker, although some lineages such as UCEC and BLCA show a favorable association.

UCEC, ESCA, and ACC are the cancer types where MUC15 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	All	0.942	0.622	.018	14	view →
ESCA	OS	Median	II,III,IV	0.103	0.868	<.001	12	view →
ACC	OS	Median	All	0.118	0.624	.038	6	view →
BLCA	DFS	Median	III,IV	1.000	0.537	.024	2	view →
STAD	OS	Median	All	0.400	0.671	.047	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

MUC15–UCEC (DFS)

Open the UCEC breakdown →