MUC15

Across TCGA pan-cancer cohorts, MUC15 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated MUC15 data layer compared with 25 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher MUC15 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated MUC15 expression acts as an unfavorable survival marker, although some lineages such as HNSC and LUAD show a favorable association.

HNSC, LUAD, and LSCC are the cancer types where MUC15 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	All	1.000	0.535	.005	16	view →
LUAD	OS	Median	III,IV	0.840	0.158	.014	3	view →
LSCC	OS	Median	All	0.595	0.888	.021	2	view →
CCRCC	OS	Quartile	All	1.000	0.250	.049	2	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

MUC15–HNSC (OS)

Open the HNSC breakdown →