MUC12

mutation — cross-omics
Cross-omicsMUTATION → RNAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, MUC12 mutation is significantly associated with the RNA expression of many other genes, with 2,043 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MUC12-associated genes across cancer lineages are OTULIN, DACT2, and ZMAT1. Each is linked with MUC12 in more than 1 cancer types. Because this analysis shows association rather than direction, both MUC12-to-partner and partner-to-MUC12 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MUC12→partner) and Y-score (partner→MUC12) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
UCECOTULIN →+0.423+3.010<.001<.00132
UCECDACT2 →-1.242-2.239<.001.00132
UCECZMAT1 →-0.568-2.137.004.00132
UCECLETM1 →+0.406+2.180.001<.00132
UCECPGAM1 →+0.745+2.928<.001<.00132
UCECKDM1A →+0.370+2.343.009.00332
Each partner links to its Q-omics profile. Showing the 6 strongest of 2,043 associations by consensus.

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