Across TCGA patient cohorts, MUC12 mutation is significantly associated with the total protein of many other genes, with 37 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MUC12-associated genes across cancer lineages are eEF2, EGFR_pY1068, and eIF4G. Each is linked with MUC12 in more than 1 cancer types. Because this analysis shows association rather than direction, both MUC12-to-partner and partner-to-MUC12 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MUC12→partner) and Y-score (partner→MUC12) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eEF2 →	+0.324	+1.502	.013	.030	3	1
UCEC	EGFR_pY1068 →	-0.239	-1.502	.009	.030	3	1
UCEC	eIF4G →	+0.289	+1.847	.011	.008	3	1
UCEC	A-Raf_pS299 →	-0.131	-2.700	.002	.006	3	1
UCEC	ERK2 →	+0.169	+1.807	.016	.025	3	1
UCEC	FOXO3a_pS318_S321 →	-0.112	-1.405	.015	.043	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 37 associations by consensus.

Exploration

MUC12 survival (RNA) · tumor vs normal (RNA) · all MUC12 data types