Across TCGA cell cohorts, MUC12 mutation is significantly associated with the RNA expression of many other genes, with 1,161 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MUC12-associated genes across cancer lineages are IFNLR1, GAL3ST3, and HOXC11. Each is linked with MUC12 in more than 2 cancer types. Because this analysis shows association rather than direction, both MUC12-to-partner and partner-to-MUC12 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MUC12→partner) and Y-score (partner→MUC12) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	IFNLR1 →	+0.651	+3.237	.002	.003	3	3
BLOOD_Lymphoma	GAL3ST3 →	+0.111	+3.745	.001	.001	3	2
SKIN	HOXC11 →	+0.633	+3.364	.006	.002	3	2
LARGE_INTESTINE	PPP3R2 →	+0.021	+1.884	.006	.006	3	2
OVARY	TPPP →	+1.055	+3.144	<.001	.007	3	2
OVARY	TNK1 →	+1.096	+3.369	.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,161 associations by consensus.

Exploration

MUC12 survival (RNA) · tumor vs normal (RNA) · all MUC12 data types