Across TCGA patient cohorts, MUC1 mutation is significantly associated with the total protein of many other genes, with 5 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MUC1-associated genes across cancer lineages are Annexin-1, STAT3_pY705, and VHL. Each is linked with MUC1 in more than 1 cancer types. Because this analysis shows association rather than direction, both MUC1-to-partner and partner-to-MUC1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MUC1→partner) and Y-score (partner→MUC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Annexin-1 →	+0.536	+2.827	.042	.035	3	1
UCEC	STAT3_pY705 →	-0.297	-3.459	.024	.005	3	1
UCEC	VHL →	-1.202	-3.000	<.001	.036	3	1
UCEC	Shc_pY317 →	-0.255	-2.321	<.001	.035	2	1
UCEC	Caspase-8 →	-0.267	-2.321	.034	.035	2	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

Exploration

MUC1 survival (RNA) · tumor vs normal (RNA) · all MUC1 data types