MTX2

Across TCGA patient cohorts, MTX2 mutation is significantly associated with the total protein of many other genes, with 14 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MTX2-associated genes across cancer lineages are JNK2, Ku80, and LKB1. Each is linked with MTX2 in more than 1 cancer types. Because this analysis shows association rather than direction, both MTX2-to-partner and partner-to-MTX2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JNK2 grouped by MTX2-low versus MTX2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MTX2→partner) and Y-score (partner→MTX2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK2 →	+0.238	+2.834	.017	.034	3	1
UCEC	Ku80 →	+0.273	+2.820	.021	.035	3	1
UCEC	LKB1 →	-0.140	-3.459	.009	.005	3	1
UCEC	Rab11 →	-0.145	-2.321	.046	.035	3	1
UCEC	S6_pS240_S244 →	+0.587	+3.459	.004	.005	3	1
UCEC	Annexin_VII →	-0.147	-2.321	.035	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

JNK2 by MTX2 expression — UCEC

Explore this box plot interactively →