MTX1

Across TCGA pan-cancer cohorts, MTX1 mass-spec protein is linked to patient survival in 8 of 34 cancer types, making it a survival-associated MTX1 data layer compared with 27 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher MTX1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated MTX1 expression acts as an unfavorable survival marker, although some lineages such as PDAC and GBM show a favorable association.

HNSC, CCRCC, and LUAD are the cancer types where MTX1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Tertile	III,IV	0.878	1.000	.014	19	view →
CCRCC	DFS	Quartile	II,III,IV	0.303	0.758	.002	16	view →
LUAD	DFS	Tertile	All	0.501	0.776	.010	13	view →
PDAC	OS	Quartile	III,IV	0.835	0.281	.006	10	view →
LSCC	DFS	Tertile	II,III,IV	0.319	0.852	.021	7	view →
GBM	DFS	Median	All	0.869	0.635	.008	6	view →
UCEC	DFS	Median	All	0.757	0.966	.001	6	view →
OV	DFS	Median	All	0.890	0.581	.022	4	view →

Pink = unfavorable, green = favorable. Showing the 8 strongest of 8 lineages.

MTX1–HNSC (DFS)

Open the HNSC breakdown →