MTUS2

Across TCGA cell cohorts, MTUS2 mutation is significantly associated with the RNA expression of many other genes, with 234 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MTUS2-associated genes across cancer lineages are GPX5, OR8B3, and SLC35G3. Each is linked with MTUS2 in more than 1 cancer types. Because this analysis shows association rather than direction, both MTUS2-to-partner and partner-to-MTUS2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GPX5 grouped by MTUS2-low versus MTUS2-high in PANCREAS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MTUS2→partner) and Y-score (partner→MTUS2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	GPX5 →	+0.022	+5.000	<.001	.006	3	2
SOFT_TISSUE	OR8B3 →	+0.018	+4.930	.002	.008	3	2
BLOOD_Leukemia	SLC35G3 →	+0.029	+2.482	<.001	.008	3	2
SKIN	HDDC2 →	+0.578	+2.743	.001	.001	3	2
LARGE_INTESTINE	GPR63 →	+0.769	+3.321	<.001	.002	3	2
SKIN	CACNA2D1 →	+1.202	+2.043	.002	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 234 associations by consensus.

GPX5 by MTUS2 expression — PANCREAS

Explore this box plot interactively →