MTURN

Across TCGA patient cohorts, MTURN mutation is significantly associated with the RNA expression of many other genes, with 4,245 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MTURN-associated genes across cancer lineages are RNA5SP411, RNA5SP412, and RPL32P8. Each is linked with MTURN in more than 1 cancer types. Because this analysis shows association rather than direction, both MTURN-to-partner and partner-to-MTURN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP411 grouped by MTURN-low versus MTURN-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MTURN→partner) and Y-score (partner→MTURN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNA5SP411 →	+1.186	+2.241	<.001	.001	3	2
UCEC	RNA5SP412 →	+0.475	+2.507	.002	<.001	3	2
BLCA	RPL32P8 →	+0.218	+5.266	<.001	.001	3	2
UCEC	RNA5SP419 →	+0.801	+2.617	<.001	<.001	3	2
UCEC	RNA5SP410 →	+0.834	+2.941	<.001	<.001	3	2
UCEC	RNA5SP422 →	+0.786	+2.211	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,245 associations by consensus.

RNA5SP411 by MTURN expression — UCEC

Explore this box plot interactively →