MTURN

Across TCGA patient cohorts, MTURN mutation is significantly associated with the total protein of many other genes, with 41 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MTURN-associated genes across cancer lineages are Shc_pY317, eEF2, and eIF4G. Each is linked with MTURN in more than 1 cancer types. Because this analysis shows association rather than direction, both MTURN-to-partner and partner-to-MTURN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Shc_pY317 grouped by MTURN-low versus MTURN-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MTURN→partner) and Y-score (partner→MTURN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Shc_pY317 →	-0.153	-2.999	.025	.035	3	2
UCEC	eEF2 →	+0.413	+3.169	.010	.018	3	1
UCEC	eIF4G →	+0.415	+3.321	.002	.009	3	1
UCEC	A-Raf_pS299 →	-0.172	-3.321	.001	.010	3	1
UCEC	ERK2 →	+0.226	+2.321	.009	.034	3	1
UCEC	FOXO3a_pS318_S321 →	-0.189	-2.700	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 41 associations by consensus.

Shc_pY317 by MTURN expression — UCEC

Explore this box plot interactively →