MTSS2

Across TCGA cell cohorts, MTSS2 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,541 significant associations in total. CNS shows the largest number of these associations.

The most reproducible MTSS2-associated GO terms across cancer lineages are Negative regulation of mRNA splicing, via spliceosome, Nucleic acid transport, and RNA transport. Each is linked with MTSS2 in more than 14 cancer types. Because this analysis shows association rather than direction, both MTSS2-to-partner and partner-to-MTSS2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of mRNA splicing, via spliceosome grouped by MTSS2-low versus MTSS2-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (MTSS2→partner) and Y-score (partner→MTSS2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Negative regulation of mRNA splicing, via spliceosome →	+0.104	+1.140	<.001	<.001	3	15
SOFT_TISSUE	Nucleic acid transport →	+0.104	+1.692	<.001	<.001	3	14
SOFT_TISSUE	RNA transport →	+0.104	+1.692	<.001	<.001	3	14
UPPER_AERODIGESTIVE_TRACT	Negative regulation of mRNA processing →	+0.096	+1.090	<.001	<.001	3	14
UPPER_AERODIGESTIVE_TRACT	Nuclear export →	+0.071	+1.276	<.001	<.001	3	14
UPPER_AERODIGESTIVE_TRACT	Establishment of RNA localization →	+0.095	+1.500	<.001	<.001	3	14

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,541 associations by consensus.

Negative regulation of mRNA splicing, via spliceosome by MTSS2 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →