MTSS2

Across TCGA cell cohorts, MTSS2 mutation is significantly associated with the RNA expression of many other genes, with 2,366 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MTSS2-associated genes across cancer lineages are CENPM, IFT27, and C12orf57. Each is linked with MTSS2 in more than 1 cancer types. Because this analysis shows association rather than direction, both MTSS2-to-partner and partner-to-MTSS2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CENPM grouped by MTSS2-low versus MTSS2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MTSS2→partner) and Y-score (partner→MTSS2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	CENPM →	+0.742	+3.169	<.001	.009	3	2
BLOOD_Leukemia	IFT27 →	+0.737	+3.489	.007	.001	3	2
BLOOD_Leukemia	C12orf57 →	+1.188	+3.215	<.001	.005	3	2
BLOOD_Leukemia	PHC1 →	+0.993	+3.285	.006	.004	3	2
BLOOD_Leukemia	GRK4 →	+0.623	+3.489	.002	.001	3	2
BLOOD_Leukemia	LLGL1 →	+1.086	+3.367	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,366 associations by consensus.

CENPM by MTSS2 expression — LARGE_INTESTINE

Explore this box plot interactively →