MTSS1

Across TCGA patient cohorts, MTSS1 mutation is significantly associated with the total protein of many other genes, with 21 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MTSS1-associated genes across cancer lineages are FoxM1, FOXO3a_pS318_S321, and PCNA. Each is linked with MTSS1 in more than 1 cancer types. Because this analysis shows association rather than direction, both MTSS1-to-partner and partner-to-MTSS1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FoxM1 grouped by MTSS1-low versus MTSS1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MTSS1→partner) and Y-score (partner→MTSS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FoxM1 →	+0.163	+1.524	.029	.008	3	2
UCEC	FOXO3a_pS318_S321 →	-0.074	-1.312	.039	.027	3	2
UCEC	PCNA →	+0.147	+1.362	.018	.031	3	2
UCEC	Cyclin-B1 →	+0.520	+2.247	.001	.001	3	2
UCEC	EGFR_pY1068 →	-0.195	-1.169	.006	.017	3	1
UCEC	Fibronectin →	-0.190	-1.212	.045	.032	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

FoxM1 by MTSS1 expression — UCEC

Explore this box plot interactively →