MTSS1

Across TCGA cell cohorts, MTSS1 mutation is significantly associated with the drug of many other genes, with 36 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MTSS1-associated genes across cancer lineages are Lenalidomide, PAK_5339, and FS112. Each is linked with MTSS1 in more than 1 cancer types. Because this analysis shows association rather than direction, both MTSS1-to-partner and partner-to-MTSS1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Lenalidomide grouped by MTSS1-low versus MTSS1-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MTSS1→partner) and Y-score (partner→MTSS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	Lenalidomide →	+0.271	+2.951	.012	.017	3	2
LARGE_INTESTINE	PAK_5339 →	+0.420	+2.649	.004	.046	3	2
BLOOD_Leukemia	FS112 →	+0.366	+2.729	.019	.039	3	1
BLOOD_Leukemia	BAY AKT1 →	+0.868	+2.658	.004	.043	3	1
BLOOD_Leukemia	BAY-MPS1 →	+0.630	+2.658	.007	.043	3	1
BLOOD_Leukemia	IGFR_3801 →	+0.572	+3.039	.039	.013	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 36 associations by consensus.

Lenalidomide by MTSS1 expression — BLOOD_Leukemia

Explore this box plot interactively →