MTRR

Across TCGA pan-cancer cohorts, MTRR mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated MTRR data layer compared with 26 for mass-spec protein and 9 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher MTRR mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated MTRR expression acts as an unfavorable survival marker, although some lineages such as LUAD show a favorable association.

LSCC, LUAD, and UCEC are the cancer types where MTRR mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	DFS	Quartile	All	0.866	1.000	.007	10	view →
LUAD	DFS	Median	III,IV	1.000	0.498	.017	9	view →
UCEC	DFS	Quartile	II,III,IV	0.633	1.000	.043	8	view →
PDAC	DFS	Median	III,IV	0.239	0.668	.005	6	view →
HNSC	DFS	Median	II,III,IV	0.910	0.981	.039	2	view →
CCRCC	OS	Median	III,IV	0.578	0.793	.039	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

MTRR–LSCC (DFS)

Open the LSCC breakdown →